August 27, 2018 Abstract Objectives: Primary: Compare the safety and tolerability of intranasal INP103 to placebo in patients with PD during an OFF episode. Secondary: Characterize the PK of single ascending doses of INP103; Explore the effect of single ascending doses of INP103 versus placebo on motor function and PK/pharmacodynamic relationship of...

November 15, 2013   Purpose Summary To compare the usability and tolerability of the Impel Precision Olfactory Delivery (POD) device to a reference conventional pump nasal spray device (CNS) in the administration of a saline dose. Background and Objectives The specific objectives of this study were to identify: • How well participants tolerated nasal saline administered by...

November 12, 2013 Purpose: In multiple species, intranasal administration of drug has been shown to bypass the blood-brain-barrier and deliver drugs directly to the central nervous system (CNS). This route of delivery has the potential to enable many therapeutics, including peptide and proteins, to reach the CNS in effective concentrations and could...