Join Impel

Impel NeuroPharma is a clinical stage pharmaceutical company based in Seattle, WA. We are committed to developing the next generation of central nervous system (CNS) drug treatments. Impel’s proprietary Precision Olfactory Delivery ™ (POD™) technology enables many categories of therapeutics, including biologics, to be delivered to the CNS using consistent and predictable intranasal drug delivery devices. We are working hard to create life-changing, innovative therapies for CNS diseases and we hope you’ll join us.

Director of Business Development

The Director of Business Development will lead ongoing and new business activities that result in licensing, partnering or acquisition of internal and/or external assets. This position will act as a strategic leader and thought partner to Impel’s leadership team and will drive key business partnerships and opportunities.

• Drive all aspects of business development efforts, including strategic partner identification, partnering, in-licensing, out-licensing and related contracting activities.
• Develop and manage relationships across a network of potential partners particularly small and large biopharmaceutical companies in the neuroscience industry
• Develop and maintain Impel’s knowledge on the interests of potential partners and competitive activities
• Coordinate evaluation of new opportunities including market and financial analyses.
• Assist in negotiation of terms and formulation of proposed offers for transaction under evaluation.
• Interact on a daily basis with cross-functional stakeholders in support of execution of ongoing transaction/development of final contracts.
• Serve as one of the company’s ambassadors to the market as a representative at industry conferences.

• Bachelor’s degree with 7-10 years’ experience in biotech/pharma business development.
• Experience in new business development activities, including customer interaction, acquisition and procurement processes, competitive assessment, and strategic planning.
• Excellent analytical skills, including familiarity with financial modeling.
• Outstanding communication skills (interpersonal, verbal and written).
• Strong leadership skills.
• Exceptional project and customer management skills.
• Excellent teamwork and collaboration skills.
• Travel expectation: 30-50%.

Director of Marketing

The Director of Marketing will be the first full time marketing hire at Impel and will initially have broad responsibility for commercial development of Impel’s pipeline of products. This includes the development and implementation of Impel’s commercial strategies for existing drug-device candidates including: market landscape and assessment (using primary and secondary data sources), TPP development, marketing and market research plan (pre-commercialization and launch), branding and messaging. It may also include assessing the commercial value of future drug-device candidates as opportunities arise. As the company quickly grows and changes with emerging clinical data over the next year, the role will evolve and may become more focused based on the needs of the company and interests of the Director.

ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned.
• Develop and execute brand strategies and brand plans including market assessment, competitive landscape review, TPP development, product positioning, promotional messaging, and multichannel marketing.
• Plans, directs, and executes all marketing strategies, functions, policies, objectives and initiatives.
• Maintain clear vision of product marketplace, focusing on new product potential, competitive developments, shift in treatment paradigm and opportunities.
• Responsible for reimbursement, access and pricing strategies and development of pricing models by segment.
• Develop appropriate marketing and advertising support (pre-commercialization and launch) for product markets including marketing communication materials, tradeshows, website, etc.
• Work with Business Development (BD) to provide input during due diligence activities that include market and competitive insights, forecasting and ROI.
• Plan and develop company marketing and communications materials. To include print media, video, webinars and other training media.

• Bachelor’s degree in Marketing, Business or life sciences required. MBA is preferred.
• 7-10 years of marketing and commercial experience in the pharmaceutical/medical device/life sciences industry.
• Experience with marketed and pipeline products, high growth companies, neuroscience and/or drug/device combinations ideal.
• Strong analytical skills and a working knowledge of business finance, pricing and forecasting.
• Deep understanding of the pharmaceutical value chain and drivers in the pharmaceutical business (Payors, Physician and Patient).
• Demonstrated high level of integrity and business ethics.
• Excellent verbal and written communication skills.
• Ability to manage multiple conflicting priorities.
• Travel expectation: 20-40%.

Sr. Specialist/Manager, Regulatory Operations

This position will be responsible for managing and executing moderately complex submission, compilation and publishing activities associated with electronic submissions and for providing subject matter expertise in eCTD implementation. The position (title) offered will be dependent on the level of experience.

ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned.

  • Prepare and/or oversee the preparation of high-quality regulatory submissions for multiple programs/products in development (e.g. IND, CTA, NDA, BLA) with a focus on eCTD.
  • Manage the review of regulatory submission documents for completeness and quality in accordance with regulatory agency requirements and standards
  • Manage projects with vendors and contractors to meet schedules and ensure quality
  • Serve as the Regulatory Operations lead, collaborating with Regulatory Affairs and the cross-functional project team to develop and implement submission strategies and timelines.
  • Provide functional and technical guidance with respect to submission of clinical trial applications and marketing applications
  • Manage and maintain regulatory information including relevant logs, trackers and archives of regulatory submissions, correspondence and commitments.
  • Manage and maintain regulatory document templates and regulatory style guide
  • Develop applicable SOPs and/or other written practices relating to the regulatory affairs operations function
  • Develop and provide training on the use of regulatory templates (i.e. StartingPoint), processes and tools critical to compiling electronic submissions (i.e., software, authoring templates and publishing tools)
  • Advise and direct evaluation, selection, and implementation of technology and equipment related to submission planning, preparation, assembly, dispatch and/or archiving
  • Assist in and/or lead the promotion of electronic initiatives in the company in support of with electronic submissions


  • Bachelor’s Degree or higher in a relevant field
  • 5+ years of direct, hands-on experience with regulatory submission and project coordination
  • 5+ years of experience with processes and standards, regulatory technology (including publishing software) and document management is required.
  • Good knowledge of drug development, FDA, and eCTD regulatory guidelines with Working knowledge/understanding of biologics and/or small molecule product development, including CMC, pre-clinical, and/or clinical development
  • Excellent oral and written communication, with particular attention to detail
  • Excellent organizational and problem-solving skills
  • Proven ability to learn and adapt in an evolving work environment
  • Advanced-level proficiency with MS Word, Excel, and Adobe Acrobat
  • Competency in MS Project, MS Visio applications and XML and SQL specifications is preferred
Director, CMC/Formulation Development

As the Director of CMC/Formulation Development, you will assure proper product and process development for Impel’s drug products, for use in Impel’s combination products, and will be responsible for technology transfer and manufacture of drug products at Impel’s CMOs. This position will require collaboration with internal teams and external contract research organizations (CROs) and contract manufacturing organizations (CMOs) for the development and manufacture of our clinical and commercial drug products.

Essential duties and responsibilities include the following. Other duties may be assigned.

  • Provide technical leadership in formulation development to support pre-clinical, clinical, and commercial programs at all development stages, drug product process development, and drug product process characterization.
  • Provide support and input to the design, execution, and delivery of formulation and process development studies for small molecule powder spray dried drug products and liquid biologic formulations.
  • Evaluate, recommend, and direct outsourced drug product development with CMOs including budget development and invoicing for formulation development, container closure/product development, and preparation of Chemistry, Manufacturing, and Controls (CMC) programs for drug products in development.
  • Develop and implement formulation, primary packaging (container closure system), and dosage form configurations to ensure stability, manufacturability, and reliability.
  • Author, review and approve documents related to GMP operations as needed and appropriate including DP Master Batch Records and Executed Batch Records.
  • Participate in multi-disciplined matrix based project teams and guide project strategies.
  • Facilitate collaboration with both internal and external drug product analytical teams, quality control and assurance, regulatory, engineering, and manufacturing.
  • Ensure that appropriate technical strategies, timelines, and budgets are in place to meet clinical supply and registration needs, and that production, technology transfer and regulatory outcomes meet or exceed industry standards.
  • Collaborate with regulatory to write and/or support CMC sections of IND filling/amendments and ethics submissions.
  • Travel to CMOs/CROs as needed.

Education, experience and/or skills required

  • Ph.D. or MS degree in Pharmaceutics, Chemistry or comparable scientific degree with a minimum 10 years of experience in the Biotech or Pharmaceutical industry; minimum 5 years leading drug product teams. Experience in development of drug-device combination products is a plus.
  • Prior experience in building and managing small molecule solid/powder formulation development from early development stages through commercial development using internal and external resources. Experience with biologic formulation development a plus.
  • Ability to apply a science-driven, phase-appropriate and risk-based analytical development strategy to deliver projects from discovery, clinical development to commercial production.
  • Experience working with CMOs, including a working knowledge of small molecule drug product validation and experience with regulatory submissions.
  • Demonstrated project management skills.
  • Strong written and verbal communication and interpersonal skills.
  • Hands-on individual with a collaborative personal style and the ability to work well in a fast-moving team/collaborative environment.
  • Highly motivated, organized, and detail-oriented.

Physical Demands

Ability to use a computer, telephone, and other office machines.

Working Conditions

This is a fast-paced environment with moderate noise level.


Travel as needed to CMOs/CROs, up to 30%.

Program Manager

The Program Manager provides cross-functional team organization, coordination, and communication for multiple Impel NeuroPharma Drug/Device Combination Product Programs.

This role leads cross-functional planning and execution of product development programs, within a matrix organization, to timely completion within budget.

The ideal candidate is an excellent leader with a positive attitude, is flexible, adapts to ever-changing requirements, organized, and can plan, execute, and manage program budgets, schedules, risks, and resources, to meet Company milestones and Key Performance Indicators.

Essential duties and responsibilities include the following. Other duties may be assigned.

  • Formulate, organize and monitor multiple cross-functional drug/device combination product Programs
  • Generate suitable program strategies, goals, milestones, and objectives
  • Coordinate cross-functional program activities
  • Develop, manage, and monitor schedules, budgets, resources, and activities to meet program milestones and corporate goals
  • Apply change, risk and resource management
  • Utilize the cross-functional team to resolve program issues, and bottlenecks, escalating to management when appropriate
  • Adapt, strategize, problem solve and respond to changing program requirements, risks and results
  • Prepare reports, summaries, and other documents for Management, using Impel Program Management tools and templates
  • Prepare reports, summaries, and other documents for external use with Board of Directors, during conferences, etc., using Impel Program Management tools and templates

Education, Experience And/Or Skills Required 

  • Minimum of 5 years of experience as a Project/Program Manager, preferably in the Medical Device, Pharmaceutical or Biotech industries
  • Minimum of Bachelor’s degree in technical discipline (engineering/biology/chemistry, etc.)
  • PMP and/or Six Sigma and/or similar certifications a plus
  • Proven knowledge and understanding of project/program management techniques and methods
  • Excellent knowledge of MS Office; working knowledge of program/project management software such as Microsoft Project or Smartsheet.
  • Outstanding leadership, communication, and organizational skills
  • Excellent problem-solving ability
  • Travel up to 10%
Senior Manufacturing Engineer

The Senior Manufacturing Engineer provides outstanding customer service to Impel’s combination product development programs by ensuring timely and technically rigorous implementation of new designs into manufacture at Impel’s Contract Manufacturing Organization(s) (CMO). The Sr Manufacturing Engineer leads the technical coordination, development, and review of manufacturing related activities. This role is responsible for the manufacturing technical transfer of design into clinical and commercial manufacture, with specific focus on injection molding and semi-automated and automated assembly lines.  This role oversees, manages, and ensures technical rigor of tool qualification and process validation at Impel’s worldwide supply base.

The ideal candidate has a positive attitude, is flexible, organized, multi-tasks, can deal with ever-changing priorities and enjoys learning new ways to create ever faster team execution and capability.  The Sr Manufacturing Engineer delivers high-quality processes and products to program deadlines.

Responsibilities include the following. Other duties may be assigned.

  • Owns technical manufacturing development within Impel’s project team
  • Manages tool qualification and process validation at suppliers worldwide
  • Evaluates technical capability and contributes to the CMO selection
  • Develops Impel’s manufacturing capacity to support manufacture of Impel product, clinical through
  • Supports Operations by participating in the planning, maintenance, and development of new, modified and/or existing manufacturing activities conducted at
  • Acts as point of contact for manufacturing related
  • Participates on technical teams for Impel’s virtual manufacturing operations.
  • Maintains adherence to medical device quality standards and regulations, with emphasis on CMC
  • Leads internal and external team efforts to resolve manufacturing issues through application of experience, technical knowledge and
  • Works closely with the Quality Assurance group to ensure that manufacturing operations at Impel’s CMOs are in control.
  • Identifies and mitigates risks associated with manufacturing processes
  • Keep key stakeholders apprised of impending manufacturing activities and challenges
  • Up to 25% travel is anticipated
  • Other projects as assigned


  • Bachelor’s degree is required.
  • Minimum 5 years of experience as a Manufacturing Engineer, Assembly Process Engineer, and/or Plastics Tooling Engineer in a fast-paced, multi-project, progressive environment
  • Must be proficient in Microsoft Office products, Proficiency with Microsoft Project or Smartsheet is a plus.
  • Must have a thorough grasp of tool qualification, process validation, process control and FDA 21 CFR 820 manufacturing requirements.
  • Must be capable of continuous learning and have a desire to take on an ever-changing list of tasks.
  • Experienced in working on a matrix cross-functional, highly collaborative product development team

Qualified candidates, please email your resumes to

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