Agitation is a common symptom of neurological and psychiatric disorders characterized by feelings of unease, excessive talking and/or unintentional and purposeless motions, such as wringing of the hands or pacing. People experiencing agitation may also express excitement, hostility, poor impulse control, tension, uncooperativeness and sometimes disruptive behavior, which could lead to aggression and violence. Acute agitation occurs in patients whose therapy for underlying disorders are not well controlled and may also be triggered by stressful situations or traumatic events. The onset of agitation may occur suddenly or slowly and vary in length of duration, lasting for a few minutes or for an extended period of time.
Agitation is a frequent symptom that is difficult to manage for approximately 90% of the 8.7 million schizophrenia and bipolar disorder patients in the United States who, on average, experience 12 agitation events per year. The severity of agitation is on a spectrum of mild to severe with a significant percentage of patients experiencing mild, moderate and intense agitation requiring intervention and treatment. A significant percentage of these agitation events lead to either admission to an inpatient treatment facility or admission to the emergency room where half of these patients will subsequently be admitted to an inpatient treatment facility. National statistics indicate there are 5.6 million inpatient treatment facility admissions per year with an average duration of 6 to 10 days and at least half of these admitted patients requiring at least four treatments for agitation during their stay.
We believe INP105 could be a preferred choice for the safe and rapid treatment of acute agitation and, being non-invasive, is well positioned to expand the treatment setting beyond the emergency room, such as inpatient treatment facilities and the patient’s home.